Medicines in development

Although there have been significant advances in HIV therapy in recent years, many treatment-related needs persist. New medicines are needed to support a broad range of patients with diverse needs and offer continued improvements in efficacy as well as other important areas for people living with HIV and physicians, such as tolerability, safety, long-term toxicity, resistance, drug‑drug interactions and convenience.

ViiV Healthcare is committed to developing new medicines for the treatment of HIV to reduce its impact on the more than 36 million people living with the virus.1 Our scientists continue to work in collaboration with GSK’s R&D team to identify new ways to lessen the burden not only of the disease, but also of daily HIV treatment.

In addition, recent results with pre-exposure prophylaxis (PrEP) for the prevention of HIV infection warrant further exploration of new delivery technologies to give people at greatest risk of HIV infection a number of prevention methods from which to choose.

Clinical development pipeline

Product

Class

Phase

dolutegravir/rilpivirine* STR

INSTI/ NNRTI

III

dolutegravir +lamivudine

INSTI + NRTI

III

LA cabotegravir + LA rilpivirine*

(for intramuscular injection)

INSTI + NNRTI

 

III

(for treatment of HIV infection)

LA cabotegravir

(for intramuscular injection)

INSTI

III

(for prevention of HIV infection)

GSK3684934

Attachment inhibitor

III

Combinectin (GSK3732394)

Entry inhibitor

I

GSK3640254

Maturation inhibitor

Pre-clinical

GSK3532795

Maturation inhibitor

Pre-clinical

*in collaboration with Janssen

INSTI= integrase strand transfer inhibitor; LA = long-acting; NNRTI = non-nucleoside reverse transcriptase inhibitor; NRTI = nucleoside reverse transcriptase inhibitor; STR = single-tablet regimen

  1. UNAIDS. Fact Sheet, November 2016. Available at: http://www.unaids.org/en/resources/fact-sheet.Last accessed January 2017.