Photo courtesy of Kevin Tachman/TREAT Asia
What we doAnnette Sohn2
Our programme supports interventions and activities that include:
- Monitoring for the emergence of advanced HIV drug-resistance in children who have failed first-line or are already on second-line ART to identify the antiretrovirals needed to optimise regimen sequencing – something that’s not been done in a structured way in other resource-limited settings.
- Applying computer-assisted survey technology and utilising mobile phone text messaging to assess and encourage adherence in adolescents growing up with HIV.
- Conducting pharmacokinetic studies of novel and second-line ARVs to evaluate dosing recommendations for Asian infants and children.
- Studying ART toxicity and outcomes, including the use of protease inhibitors and switch practices among adolescents.
- Examining reproductive health issues by studying use of oral contraceptives and drug interactions with ART, in order to inform a model of reproductive health services for adolescent females living with HIV in Asia. One hundred sexually active HIV-positive adolescent females and young women between 12 and 24 years of age will be enrolled in this project.
- Annette Sohn3 Studying prevention of bone demineralisation in children and adolescents in Asia. This 48-week study will be conducted at sites in Thailand and Indonesia among almost 250 adolescents.
- Educating paediatricians on treatment failure, drug resistance, lipodystrophy management and optimisation of ART sequencing for children.
- Research-capacity building and training for paediatric HIV providers.
- Advocating for safe and effective HIV care and treatment for children in the region and across the globe.